The CADASIL Hub

CADASIL

CADASIL is the most common inherited cause of stroke and vascular dementia in adults. It's caused by a mutation in the NOTCH3 gene that damages the brain's small blood vessels, leading to migraines, repeated strokes, and gradual cognitive decline. There is no cure yet, but the disease course varies widely and can be influenced.

If your family has been touched by CADASIL, you already know how alone it can feel — a disease most doctors have never treated, with a name almost no one can say. This hub exists to give you the truth, in plain language, with every claim sourced. Start with what CADASIL is, then move at your own pace: symptoms, diagnosis, treatment, and the parts nobody explains — money, insurance, and how to actually live with it.